Neuroprotective effects of PACAP against ethanol-induced toxicity in the developing rat cerebellum.
Identifieur interne : 000754 ( Main/Exploration ); précédent : 000753; suivant : 000755Neuroprotective effects of PACAP against ethanol-induced toxicity in the developing rat cerebellum.
Auteurs : Béatrice Botia [France] ; Valérie Jolivel [France] ; Delphine Burel [France] ; Vadim Le Joncour [France] ; Vincent Roy [France] ; Mickael Naassila [France] ; Magalie Bénard [France] ; Alain Fournier [France] ; Hubert Vaudry [France] ; David Vaudry [France]Source :
- Neurotoxicity Research [ 1029-8428 ] ; 2011-04.
Abstract
The developing rat cerebellum is particularly sensitive to alcohol at the end of the first postnatal week, a period of intense neurogenesis. The neuropeptide Pituitary adenylate cyclase-activating polypeptide (PACAP) has previously been shown to prevent the death of cultured neurons in vitro. We have thus investigated the capacity of PACAP to counteract ethanol toxicity in 8-day-old rats. Behavioral studies revealed that PACAP reduces the deleterious action of alcohol in the negative geotaxis test. Administration of ethanol induced a transient increase of the expression of pro-apoptotic genes including c-jun or caspase-3 , which could be partially blocked by PACAP. Alcohol inhibited the expression of the α6 GABA ( A ) subunit while PACAP increased neuroD2 mRNA level, two markers of neuronal differentiation. Although gene regulations occurred rapidly, a third injection of ethanol was required to strongly reduce the number of granule cells in the internal granule cell layer, an effect which was totally blocked by PACAP. The action of PACAP was mimicked by D-JNKi1 and Z-VAD-FMK, indicating the involvement of the jun and caspase-3 pathways in alcohol toxicity. The present data demonstrate that PACAP can counteract in vivo the deleterious effect of ethanol. The beneficial action of PACAP on locomotor activity precedes its activity on cell survival, indicating that PACAP can block the detrimental action of ethanol on cell differentiation.
Url:
DOI: 10.1007/s12640-010-9186-y
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000235
- to stream Hal, to step Curation: 000235
- to stream Hal, to step Checkpoint: 000379
- to stream Main, to step Merge: 000759
- to stream Main, to step Curation: 000754
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuroprotective effects of PACAP against ethanol-induced toxicity in the developing rat cerebellum.</title><author><name sortKey="Botia, Beatrice" sort="Botia, Beatrice" uniqKey="Botia B" first="Béatrice" last="Botia">Béatrice Botia</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106121" status="VALID"><orgName>Différenciation et communication neuronale et neuroendocrine</orgName><orgName type="acronym">DC2N</orgName><desc><address><addrLine>Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation name="U982" active="#struct-303623" type="direct"></relation><relation name="EA4310" active="#struct-300318" type="direct"></relation></listRelation><tutelles><tutelle name="U982" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="EA4310" active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Jolivel, Valerie" sort="Jolivel, Valerie" uniqKey="Jolivel V" first="Valérie" last="Jolivel">Valérie Jolivel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106121" status="VALID"><orgName>Différenciation et communication neuronale et neuroendocrine</orgName><orgName type="acronym">DC2N</orgName><desc><address><addrLine>Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation name="U982" active="#struct-303623" type="direct"></relation><relation name="EA4310" active="#struct-300318" type="direct"></relation></listRelation><tutelles><tutelle name="U982" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="EA4310" active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Burel, Delphine" sort="Burel, Delphine" uniqKey="Burel D" first="Delphine" last="Burel">Delphine Burel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106121" status="VALID"><orgName>Différenciation et communication neuronale et neuroendocrine</orgName><orgName type="acronym">DC2N</orgName><desc><address><addrLine>Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation name="U982" active="#struct-303623" type="direct"></relation><relation name="EA4310" active="#struct-300318" type="direct"></relation></listRelation><tutelles><tutelle name="U982" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="EA4310" active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Le Joncour, Vadim" sort="Le Joncour, Vadim" uniqKey="Le Joncour V" first="Vadim" last="Le Joncour">Vadim Le Joncour</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106121" status="VALID"><orgName>Différenciation et communication neuronale et neuroendocrine</orgName><orgName type="acronym">DC2N</orgName><desc><address><addrLine>Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation name="U982" active="#struct-303623" type="direct"></relation><relation name="EA4310" active="#struct-300318" type="direct"></relation></listRelation><tutelles><tutelle name="U982" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="EA4310" active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Roy, Vincent" sort="Roy, Vincent" uniqKey="Roy V" first="Vincent" last="Roy">Vincent Roy</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1752" status="OLD"> <orgName>IFR multidisciplinaire sur les peptides</orgName> <orgName type="acronym">IMP</orgName> <desc> <address> <addrLine>Place Emile Blondel 76821 Mont Saint Aignan cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-rouen.fr/ifrmp23</ref> </desc> <listRelation> <relation active="#struct-300147" type="direct"></relation> <relation active="#struct-300317" type="direct"></relation> <relation active="#struct-300318" type="direct"></relation> <relation active="#struct-301860" type="direct"></relation> <relation name="IFR23" active="#struct-303623" type="direct"></relation> <relation name="IFR23" active="#struct-441569" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-300147" type="direct"><org type="institution" xml:id="struct-300147" status="VALID"><orgName>CHU Rouen</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300317" type="direct"><org type="institution" xml:id="struct-300317" status="VALID"><orgName>Université du Havre</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle><tutelle active="#struct-301860" type="direct"><org type="institution" xml:id="struct-301860" status="VALID"> <orgName>CRLCC Henri Becquerel</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle name="IFR23" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="IFR23" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Le Havre</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université du Havre</orgName><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Naassila, Mickael" sort="Naassila, Mickael" uniqKey="Naassila M" first="Mickael" last="Naassila">Mickael Naassila</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-27773" status="VALID"><orgName>Alcoolisation précoce et vulnerabilité à la dépendance</orgName><desc><address><addrLine>faculte de pharmacie 1, rue des louvels 80037 AMIENS CEDEX 1</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300258" type="direct"></relation><relation name="ERI24" active="#struct-303623" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300258" type="direct"><org type="institution" xml:id="struct-300258" status="VALID"><orgName>Université de Picardie Jules Verne</orgName><orgName type="acronym">UPJV</orgName><desc><address><addrLine>Chemin du Thil - 80000 Amiens</addrLine><country key="FR"></country></address><ref type="url">https://www.u-picardie.fr/</ref></desc></org></tutelle><tutelle name="ERI24" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Benard, Magalie" sort="Benard, Magalie" uniqKey="Benard M" first="Magalie" last="Bénard">Magalie Bénard</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2833" status="VALID"><orgName>Neuroendocrinologie cellulaire et moléculaire</orgName><desc><address><addrLine>Universite de Rouen 76821 MONT-SAINT-AIGNAN CEDEX</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/jsp/fiche_structure.jsp?STNAV=SGR&RUBNAV=&CODE=LNCM&LANGUE=0</ref></desc><listRelation><relation name="IFR23" active="#struct-303623" type="direct"></relation><relation name="U413" active="#struct-303623" type="direct"></relation><relation active="#struct-300318" type="direct"></relation></listRelation><tutelles><tutelle name="IFR23" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="U413" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Fournier, Alain" sort="Fournier, Alain" uniqKey="Fournier A" first="Alain" last="Fournier">Alain Fournier</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-206074" status="INCOMING"><orgName>International Associated Laboratory Samuel De Champlain</orgName><desc><address><addrLine>Mont-Saint-Aignan</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-350489" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-350489" type="direct"><org type="institution" xml:id="struct-350489" status="INCOMING"><orgName>International Associated Laboratory Samuel De Champlain</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Vaudry, Hubert" sort="Vaudry, Hubert" uniqKey="Vaudry H" first="Hubert" last="Vaudry">Hubert Vaudry</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106121" status="VALID"><orgName>Différenciation et communication neuronale et neuroendocrine</orgName><orgName type="acronym">DC2N</orgName><desc><address><addrLine>Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation name="U982" active="#struct-303623" type="direct"></relation><relation name="EA4310" active="#struct-300318" type="direct"></relation></listRelation><tutelles><tutelle name="U982" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="EA4310" active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Vaudry, David" sort="Vaudry, David" uniqKey="Vaudry D" first="David" last="Vaudry">David Vaudry</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106121" status="VALID"><orgName>Différenciation et communication neuronale et neuroendocrine</orgName><orgName type="acronym">DC2N</orgName><desc><address><addrLine>Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation name="U982" active="#struct-303623" type="direct"></relation><relation name="EA4310" active="#struct-300318" type="direct"></relation></listRelation><tutelles><tutelle name="U982" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="EA4310" active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:inserm-00746164</idno><idno type="halId">inserm-00746164</idno><idno type="halUri">http://www.hal.inserm.fr/inserm-00746164</idno><idno type="url">http://www.hal.inserm.fr/inserm-00746164</idno><idno type="doi">10.1007/s12640-010-9186-y</idno><date when="2011-04">2011-04</date><idno type="wicri:Area/Hal/Corpus">000235</idno><idno type="wicri:Area/Hal/Curation">000235</idno><idno type="wicri:Area/Hal/Checkpoint">000379</idno><idno type="wicri:doubleKey">1029-8428:2011:Botia B:neuroprotective:effects:of</idno><idno type="wicri:Area/Main/Merge">000759</idno><idno type="wicri:Area/Main/Curation">000754</idno><idno type="wicri:Area/Main/Exploration">000754</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neuroprotective effects of PACAP against ethanol-induced toxicity in the developing rat cerebellum.</title><author><name sortKey="Botia, Beatrice" sort="Botia, Beatrice" uniqKey="Botia B" first="Béatrice" last="Botia">Béatrice Botia</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106121" status="VALID"><orgName>Différenciation et communication neuronale et neuroendocrine</orgName><orgName type="acronym">DC2N</orgName><desc><address><addrLine>Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation name="U982" active="#struct-303623" type="direct"></relation><relation name="EA4310" active="#struct-300318" type="direct"></relation></listRelation><tutelles><tutelle name="U982" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="EA4310" active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Jolivel, Valerie" sort="Jolivel, Valerie" uniqKey="Jolivel V" first="Valérie" last="Jolivel">Valérie Jolivel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106121" status="VALID"><orgName>Différenciation et communication neuronale et neuroendocrine</orgName><orgName type="acronym">DC2N</orgName><desc><address><addrLine>Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation name="U982" active="#struct-303623" type="direct"></relation><relation name="EA4310" active="#struct-300318" type="direct"></relation></listRelation><tutelles><tutelle name="U982" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="EA4310" active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Burel, Delphine" sort="Burel, Delphine" uniqKey="Burel D" first="Delphine" last="Burel">Delphine Burel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106121" status="VALID"><orgName>Différenciation et communication neuronale et neuroendocrine</orgName><orgName type="acronym">DC2N</orgName><desc><address><addrLine>Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation name="U982" active="#struct-303623" type="direct"></relation><relation name="EA4310" active="#struct-300318" type="direct"></relation></listRelation><tutelles><tutelle name="U982" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="EA4310" active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Le Joncour, Vadim" sort="Le Joncour, Vadim" uniqKey="Le Joncour V" first="Vadim" last="Le Joncour">Vadim Le Joncour</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106121" status="VALID"><orgName>Différenciation et communication neuronale et neuroendocrine</orgName><orgName type="acronym">DC2N</orgName><desc><address><addrLine>Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation name="U982" active="#struct-303623" type="direct"></relation><relation name="EA4310" active="#struct-300318" type="direct"></relation></listRelation><tutelles><tutelle name="U982" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="EA4310" active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Roy, Vincent" sort="Roy, Vincent" uniqKey="Roy V" first="Vincent" last="Roy">Vincent Roy</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-1752" status="OLD"> <orgName>IFR multidisciplinaire sur les peptides</orgName> <orgName type="acronym">IMP</orgName> <desc> <address> <addrLine>Place Emile Blondel 76821 Mont Saint Aignan cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-rouen.fr/ifrmp23</ref> </desc> <listRelation> <relation active="#struct-300147" type="direct"></relation> <relation active="#struct-300317" type="direct"></relation> <relation active="#struct-300318" type="direct"></relation> <relation active="#struct-301860" type="direct"></relation> <relation name="IFR23" active="#struct-303623" type="direct"></relation> <relation name="IFR23" active="#struct-441569" type="direct"></relation> </listRelation><tutelles><tutelle active="#struct-300147" type="direct"><org type="institution" xml:id="struct-300147" status="VALID"><orgName>CHU Rouen</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300317" type="direct"><org type="institution" xml:id="struct-300317" status="VALID"><orgName>Université du Havre</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle><tutelle active="#struct-301860" type="direct"><org type="institution" xml:id="struct-301860" status="VALID"> <orgName>CRLCC Henri Becquerel</orgName> <desc> <address> <country key="FR"></country> </address> </desc></org></tutelle><tutelle name="IFR23" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="IFR23" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Le Havre</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université du Havre</orgName><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Naassila, Mickael" sort="Naassila, Mickael" uniqKey="Naassila M" first="Mickael" last="Naassila">Mickael Naassila</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-27773" status="VALID"><orgName>Alcoolisation précoce et vulnerabilité à la dépendance</orgName><desc><address><addrLine>faculte de pharmacie 1, rue des louvels 80037 AMIENS CEDEX 1</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300258" type="direct"></relation><relation name="ERI24" active="#struct-303623" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300258" type="direct"><org type="institution" xml:id="struct-300258" status="VALID"><orgName>Université de Picardie Jules Verne</orgName><orgName type="acronym">UPJV</orgName><desc><address><addrLine>Chemin du Thil - 80000 Amiens</addrLine><country key="FR"></country></address><ref type="url">https://www.u-picardie.fr/</ref></desc></org></tutelle><tutelle name="ERI24" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Benard, Magalie" sort="Benard, Magalie" uniqKey="Benard M" first="Magalie" last="Bénard">Magalie Bénard</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2833" status="VALID"><orgName>Neuroendocrinologie cellulaire et moléculaire</orgName><desc><address><addrLine>Universite de Rouen 76821 MONT-SAINT-AIGNAN CEDEX</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/jsp/fiche_structure.jsp?STNAV=SGR&RUBNAV=&CODE=LNCM&LANGUE=0</ref></desc><listRelation><relation name="IFR23" active="#struct-303623" type="direct"></relation><relation name="U413" active="#struct-303623" type="direct"></relation><relation active="#struct-300318" type="direct"></relation></listRelation><tutelles><tutelle name="IFR23" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="U413" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Fournier, Alain" sort="Fournier, Alain" uniqKey="Fournier A" first="Alain" last="Fournier">Alain Fournier</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-206074" status="INCOMING"><orgName>International Associated Laboratory Samuel De Champlain</orgName><desc><address><addrLine>Mont-Saint-Aignan</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-350489" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-350489" type="direct"><org type="institution" xml:id="struct-350489" status="INCOMING"><orgName>International Associated Laboratory Samuel De Champlain</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Vaudry, Hubert" sort="Vaudry, Hubert" uniqKey="Vaudry H" first="Hubert" last="Vaudry">Hubert Vaudry</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106121" status="VALID"><orgName>Différenciation et communication neuronale et neuroendocrine</orgName><orgName type="acronym">DC2N</orgName><desc><address><addrLine>Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation name="U982" active="#struct-303623" type="direct"></relation><relation name="EA4310" active="#struct-300318" type="direct"></relation></listRelation><tutelles><tutelle name="U982" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="EA4310" active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author><author><name sortKey="Vaudry, David" sort="Vaudry, David" uniqKey="Vaudry D" first="David" last="Vaudry">David Vaudry</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-106121" status="VALID"><orgName>Différenciation et communication neuronale et neuroendocrine</orgName><orgName type="acronym">DC2N</orgName><desc><address><addrLine>Place Emile Blondel Faculté des Sciences et Techniques 76821 Mont-Saint-Aignan Cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation name="U982" active="#struct-303623" type="direct"></relation><relation name="EA4310" active="#struct-300318" type="direct"></relation></listRelation><tutelles><tutelle name="U982" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="EA4310" active="#struct-300318" type="direct"><org type="institution" xml:id="struct-300318" status="VALID"><orgName>Université de Rouen</orgName><desc><address><addrLine> 1 rue Thomas Becket - 76821 Mont-Saint-Aignan</addrLine><country key="FR"></country></address><ref type="url">http://www.univ-rouen.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rouen</settlement><region type="region" nuts="2">Région Normandie</region><region type="old region" nuts="2">Haute-Normandie</region></placeName><orgName type="university">Université de Rouen</orgName></affiliation></author></analytic><idno type="DOI">10.1007/s12640-010-9186-y</idno><series><title level="j">Neurotoxicity Research</title><idno type="ISSN">1029-8428</idno><imprint><date type="datePub">2011-04</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The developing rat cerebellum is particularly sensitive to alcohol at the end of the first postnatal week, a period of intense neurogenesis. The neuropeptide Pituitary adenylate cyclase-activating polypeptide (PACAP) has previously been shown to prevent the death of cultured neurons in vitro. We have thus investigated the capacity of PACAP to counteract ethanol toxicity in 8-day-old rats. Behavioral studies revealed that PACAP reduces the deleterious action of alcohol in the negative geotaxis test. Administration of ethanol induced a transient increase of the expression of pro-apoptotic genes including c-jun or caspase-3 , which could be partially blocked by PACAP. Alcohol inhibited the expression of the α6 GABA ( A ) subunit while PACAP increased neuroD2 mRNA level, two markers of neuronal differentiation. Although gene regulations occurred rapidly, a third injection of ethanol was required to strongly reduce the number of granule cells in the internal granule cell layer, an effect which was totally blocked by PACAP. The action of PACAP was mimicked by D-JNKi1 and Z-VAD-FMK, indicating the involvement of the jun and caspase-3 pathways in alcohol toxicity. The present data demonstrate that PACAP can counteract in vivo the deleterious effect of ethanol. The beneficial action of PACAP on locomotor activity precedes its activity on cell survival, indicating that PACAP can block the detrimental action of ethanol on cell differentiation.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Haute-Normandie</li><li>Région Normandie</li></region><settlement><li>Le Havre</li><li>Rouen</li></settlement><orgName><li>Université de Rouen</li><li>Université du Havre</li></orgName></list><tree><country name="France"><region name="Région Normandie"><name sortKey="Botia, Beatrice" sort="Botia, Beatrice" uniqKey="Botia B" first="Béatrice" last="Botia">Béatrice Botia</name></region><name sortKey="Benard, Magalie" sort="Benard, Magalie" uniqKey="Benard M" first="Magalie" last="Bénard">Magalie Bénard</name><name sortKey="Burel, Delphine" sort="Burel, Delphine" uniqKey="Burel D" first="Delphine" last="Burel">Delphine Burel</name><name sortKey="Fournier, Alain" sort="Fournier, Alain" uniqKey="Fournier A" first="Alain" last="Fournier">Alain Fournier</name><name sortKey="Jolivel, Valerie" sort="Jolivel, Valerie" uniqKey="Jolivel V" first="Valérie" last="Jolivel">Valérie Jolivel</name><name sortKey="Le Joncour, Vadim" sort="Le Joncour, Vadim" uniqKey="Le Joncour V" first="Vadim" last="Le Joncour">Vadim Le Joncour</name><name sortKey="Naassila, Mickael" sort="Naassila, Mickael" uniqKey="Naassila M" first="Mickael" last="Naassila">Mickael Naassila</name><name sortKey="Roy, Vincent" sort="Roy, Vincent" uniqKey="Roy V" first="Vincent" last="Roy">Vincent Roy</name><name sortKey="Vaudry, David" sort="Vaudry, David" uniqKey="Vaudry D" first="David" last="Vaudry">David Vaudry</name><name sortKey="Vaudry, Hubert" sort="Vaudry, Hubert" uniqKey="Vaudry H" first="Hubert" last="Vaudry">Hubert Vaudry</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/France/explor/LeHavreV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000754 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000754 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/France
|area= LeHavreV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Hal:inserm-00746164
|texte= Neuroprotective effects of PACAP against ethanol-induced toxicity in the developing rat cerebellum.
}}
| This area was generated with Dilib version V0.6.25. |  |